The Philadelphia Eagles are set to face the San Francisco 49ers this Sunday, January 14, 2026, in a crucial NFC Wild Card matchup at Lincoln Financial Field. The Eagles, entering the game as the No. 3 seed with an 11-6 record, will confront a formidable 49ers team that boasts a 12-5 record and has won six of its last seven games with quarterback Brock Purdy leading the charge.
A significant development for Philadelphia comes from the news surrounding All-Pro right tackle Lane Johnson. After practicing for three consecutive days, Johnson’s potential return is a welcome boost for a lineup that is otherwise in strong health. In contrast, the 49ers are grappling with a more precarious injury situation. Star left tackle Trent Williams is listed as questionable due to a hamstring issue, while wide receiver Ricky Pearsall is also uncertain after missing substantial practice time.
The absence of Williams has notably impacted San Francisco’s rushing performance, which has struggled, averaging just 2.8 yards per carry to the left side during his absence. This disparity between the Eagles’ solid lineup and the 49ers’ battered offensive line has led analysts to reassess the odds for this high-stakes encounter.
Current Betting Odds and Predictions
As the teams prepare for their clash, analysts have compiled updated betting odds to reflect the evolving dynamics. According to betting sources, the spread currently sits at 49ers +6 (-110) and Eagles -6 (-108). The moneyline is set at 49ers +225 and Eagles -265, with the over/under total at 44.5 points. These figures represent the latest available odds from selected sportsbooks and are subject to change as game day approaches.
Utilizing advanced data analysis and machine learning, experts at Dimers.com have conducted 10,000 simulations of the upcoming game. Their predictive model suggests that the Eagles have a 69% chance of securing a victory against the 49ers. Furthermore, the model indicates that the 49ers have a 54% probability of covering the spread, while the over/under of 44.5 points is viewed as a coin flip, each side having a 50% chance of hitting.
Expert Insights and Player Projections
Dimers.com has released their best betting advice for the game, recommending a wager on the 49ers +6 (-110). This recommendation is based on meticulous simulations and strategic insights aimed at assisting bettors in making informed decisions.
The predicted final score from the simulations foresees the Eagles coming out on top with a score of 24-19. This estimate reflects each team’s average performance based on the extensive simulations conducted.
In terms of player performances, several key athletes are expected to make significant impacts. For the 49ers, running back Christian McCaffrey is projected to be a notable contributor, with a 58.3% chance of scoring at any point in the game. Quarterback Brock Purdy is anticipated to throw for approximately 229 yards, while tight end George Kittle may lead in receiving yards with an expected 58.
On the Eagles’ side, running back Saquon Barkley emerges as a potential first touchdown scorer, holding an 11.4% probability. Quarterback Jalen Hurts is projected for around 215 passing yards, with wide receiver A.J. Brown expected to lead in receiving yards at 71.
As fans gear up for this pivotal Wild Card matchup, the anticipation builds around the performance of both teams, particularly in light of the injuries affecting the 49ers. The game is scheduled to start at 16:30 EST, promising a thrilling contest between two playoff contenders.
As always, it is crucial for bettors to engage in responsible gambling practices and rely on reputable sources for the latest information and updates leading up to the game.
