Research published on October 29, 2025, in the Journal of Periodontology reveals a significant association between antidepressant use and a lower prevalence of periodontitis. The study, conducted by a team led by María Martínez from the University Complutense in Madrid, analyzed data from 9,839 participants in the U.S. National Health and Nutrition Examination Survey spanning from 2009 to 2014.
The findings indicate that the overall prevalence of periodontitis among the studied population was 35.3% for moderate cases and 11.1% for severe cases. Notably, the researchers discovered that individuals using antidepressants had reduced odds of developing periodontitis, particularly in severe cases. The adjusted odds ratio for advanced periodontitis (stages III to IV) was recorded at 0.68, while the odds ratio for severe periodontitis was 0.41.
Implications of the Findings
The study’s results provide compelling evidence that antidepressant medications may play a role in protecting against severe periodontal disease. “We have known for a long time that depression and gum disease can influence each other,” stated Ana Becil Giglio, president of the American Academy of Periodontology. “This study adds an intriguing new layer, suggesting that antidepressant use may help protect against severe forms of periodontal disease.”
The research highlights the complex relationship between mental health and physical health, particularly in the context of dental health. The connection between depression and oral health issues emphasizes the need for healthcare providers to consider mental health treatment as part of comprehensive dental care.
Further investigation into this relationship could lead to enhanced treatment protocols that integrate mental health management with dental health strategies. As the study indicates, addressing depression may not only improve mental well-being but also reduce the risk of developing serious oral health conditions such as periodontitis.
For those interested in further details, the full study is available in the Journal of Periodontology, authored by María Martínez and colleagues. The findings underscore the importance of multidisciplinary approaches in healthcare, particularly in managing conditions that intertwine mental and physical health.
